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Secondary Metabolites from Microorganisms
isolated by the HP Fiedler Group

Simocyclinones A–D

Producing organism: Streptomyces antibioticus Tü 6040

Habitat: terrestrial; Iguaçu Falls, Argentina
Screening method: HPLC-DAD
Biological activity: antibacterial, inhibitors of bacterial gyrase (simocyclinones D); antitumor, inhibitors of protein kinase C (simo¬cyclinones C and D)

References

  • Schimana, J.; H.-P. Fiedler, I. Groth, R. Süssmuth, W. Beil, M. Walker & A. Zeeck. J. Antibiotics 53: 779-787, 2000
    Theobald, U.; J. Schimana & H.-P. Fiedler. Antonie van Leeuwenhoek 78: 307-313, 2000
    Schimana, J.; M. Walker, A. Zeeck & H.-P. Fiedler. J. Ind. Microbiol. Biotechnol. 27: 144-148, 2001
    Holzenkämpfer, M.; M. Walker, A. Zeeck, J. Schimana & H.-P. Fiedler. J. Antibiotics 55: 301-307, 2002
    Trefzer, A.; S. Pelzer, J. Schimana, S. Stockert, C. Bihlmaier, H.-P. Fiedler, K. Welzel, A. Vente & A. Bechthold. Antimicrob. Agents Chemother. 46: 1174-1182, 2002
    Galm, U.; J. Schimana, H.-P. Fiedler, J. Schmidt, S.-M. Li & L. Heide. Arch. Microbiol. 178: 102-114, 2002
    Flatman, R.H.; A.J. Howells, L. Heide, H.-P. Fiedler & A. Maxwell. Antimicrob. Agents Chemother. 49: 1093-1100, 2005
    Oppegard, L.M.; B.L. Hamann, K.R. Streck, K.C. Ellis, H.-P. Fiedler, A.B. Khodursky & H. Hiasa. Antimicrob. Agents Chemother. 53:2110-2119, 2009
    Le, T.B.K.; H.-P. Fiedler, C.D. den Hengst, S.K. Ahn, A. Maxwell & M.J. Buttner. Molec. Microbiol. 72: 1462-1474, 2009
    Edwards, M.J.; R.H. Flatman, L.A. Mitchenall, C.E.M. Stevenson, T.B.K. Le, T.A. Clarke, A.R. McKay, H.-P. Fiedler, M.J. Buttner, D.M. Lawson & A. Maxwell. Science 326: 1415-1417, 2009

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