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Secondary Metabolites from Microorganisms
isolated by the HP Fiedler Group

Gombapyrones A–D

Producing organism: Streptomyces griseoruber Acta 3662

Habitat: terrestrial; rhizosphere of bamboo trees, Gombak, Malaysia
Screening method: HPLC-DAD
Biological activity: inhibitors of protein tyrosine phosphatase 1B and glycogen synthase kinase 3?


  • Helaly, S.; K. Schneider, J. Nachtigall, S. Vikineswary, G.Y.A. Tan, H. Zinecker, J.F. Imhoff, R.D. Süssmuth & H.-P. Fiedler. J. Antibiotics 62: 445-452, 2009

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